Mass Effect Andromeda takes us on an adventure in a new part of space, some 600 years after the events of the original trilogy. Of course, we should expect a few changes, but one notable difference that the developers are talking about, is how some of the races you knew of may not be present in this part of space.
Perhaps they became extinct. That’s another possibility, but it would kill off potential story arcs, so let’s just say that they haven’t ventured this far into the unknown yet. According to Game Informer’s interview with Bioware, they have retrieved quite a lot of information, as well as this bit about the races of the Milky Way.
In the interview, it is said that “Not all of the races from the original trilogy appear in Andromeda, but they may show up in future installments. “We’ve designed the IP in such a way that they can all show up,” Mac Walters, Mass Effect Andromeda’s creative director says. “For hopefully obvious reasons, they’re not all going to show up in the first game.”
From what we have seen so far, humans are the mainstay of the series, seeing as you play as one. In the same interview, it is said that 20,000 humans are still asleep on the Hyperion when Ryder (you) wakes up at the beginning of the game. Turians also play a part, but in Mass Effect lore, they’re the first race humans encountered in space, hence the First Contact War. Salarians are also involved, with one piloting your ship instead of Joker this time around. Lastly, we have Asari, with one of them being a member of your squad, as seen in gameplay clips.
Mass Effect Andromeda is still a few months out from release, with a rumoured March release window in pencil. There are some more interesting pieces of information on the Game Informer article which you can read here.